Lanthanum nitrate

Synthesis

Lanthanum nitrate is obtained by dissolving lanthanum oxide or lanthanum hydroxide in dilute nitric acid solution and crystallization after evaporation in a water bath.

Characteristics

Deliquescent and oxidizing. Hazardous chemicals. Human inhalation of lanthanum and its compounds fume can cause headache, nausea and other symptoms, and even lead to death in severe cases. Lanthanum nitrate has combustion-supporting properties, and it is an explosive product.

Biological Activity

Low-dose excitatory effect of lanthanum nitrate on learning and memory in mice and its relationship with phosphorylation levels of cAMP response element binding protein (CREB) and Jun-amino-terminal kinase (JNK) proteins. ICR mice were exposed to 0.002, 0.02, 0.2, 2, and 20 mg/kg lanthanum nitrate for 4 weeks, and the reaction time and the number of errors in the water maze were measured every day. The content of p-CREB and p-JNK was determined. [Results] The reaction time of the water maze of mice showed a trend of shortening gradually and then gradually increasing with the increase of the dose at the 4th week of exposure. The reaction time of the 0.2 mg/kg group was the shortest; while the number of errors appeared Contrary to the trend, the 2mg/kg group had the least number of errors. The phosphorylation levels of CREB (6.20±3.2) and JNK (4.11±2.92) in the hippocampus of mice in the 0.2 mg/kg dose group were increased after oral exposure to lanthanum nitrate for 4 weeks. Compared with the solvent control group, the difference was significant. sex. There was no significant difference in cortical CREB and JNK phosphorylation in mice exposed to different doses of lanthanum nitrate compared with the control group. Oral exposure to lanthanum nitrate can increase the phosphorylation levels of CREB and JNK proteins in the hippocampus of mice, which is consistent with the trend of changes in the learning and memory ability of mice, suggesting that low-dose lanthanum nitrate may induce the phosphorylation levels of learning-related proteins by increasing the level of phosphorylation. It can promote the spatial learning and memory of mice.